Screening for Antibacterial Activity of French Mushrooms against Pathogenic and Multidrug Resistant Bacteria

In the alarming context of antibiotic resistance, we explored antibacterial potential French mushrooms against wild-type and multidrug-resistant (MDR) bacteria. order to accelerate discovery promising compounds, screenings were carried out by TLC-direct bioautography. A total 70 extracts from 31 mushroom species evaluated five bacteria: Staphylococcus epidermidis, aureus, Enterococcus faecalis, Escherichia coli, Pseudomonas aeruginosa. This first screening revealed that 95% contained compounds. Generally, it was observed EtOAc exhibited more active compounds than methanolic extracts. addition, all overall Gram-positive bacteria Gram-negative strains. The most then screened various strains S. aureus E. coli. Activity globally less on MDR strains; however, two species, Fomitopsis pinicola Scleroderma citrinum, still several inhibiting growth these pathogenic Stearic acid identified as a ubiquitous compound contributing defence mushrooms. macromycetes source compounds; further assays are necessary consider fungal drugs counter resistance.